Adult

Amoxicillin

General information

A penicillin antibiotic. Do NOT use if patient is allergic to penicillin.

Formulary antimicrobial: Use in accordance with Trust guidelines  

AWaRe antibiotic classification: 'Access'. Use as per guidelines.

For all information regarding contra-indications, interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC)

Dosing

 

Oral amoxicillin

Intravenous amoxicillin

Standard dose

500mg - 1g TDS

1g TDS

Severe infection

  

2g TDS

Listeria meningitis or infective endocarditis (on the advice of Micro/ID)

  

2g 4-hourly

(Maximum 12g per day)

Obesity

Dosing should be at the upper end of recommended ranges, particularly for morbidly obese patient with severe infection, considering patient’s renal function.

Renal and hepatic impairment

Renal impairment

eGFR (mL/min/1.73m2)

amoxicillin dose (oral or intravenous)

10 or more

Dose as in normal renal function

Less than 10

250mg–1g every 8 hours

Endocarditis or listeria meningitis: Maximum 6g per day 

HDF/High Flux

Dialysed; give post-dialysis on dialysis days.

Dose as in eGFR less than 10ml/min/1.73m2

PD

Not dialysed.

Dose as in eGFR less than 10ml/min/1.73m2

Note: Doses are based on Renal Drug Database

 

Hepatic impairment

No dose adjustment required. Hepatic function to be monitored regularly.

References

  1. Bowmed Ibisqus Limited. Amoxicillin 1g powder for solution for injection vials summary of product characteristics. Electronic medicines compendium. Last revision of the text 24/7/23. Accessed via www.medicines.org.uk Accessed 04/11/26.
  2. Aurobindo Pharma - Milpharm Ltd. Amoxicillin 500mg Capsules summary of product characteristics. Electronic medicines compendium. Last revision of the text 25/3/25. Accessed via www.medicines.org.uk Accessed 04/11/26.
  3. British National Formulary. Amoxicillin. BNF online accessed via www.medicinescomplete.com Accessed 04/11/26.
  4. The Renal Drug Database. Amoxicillin. Last updated 13/4/26. Accessed via https://renaldrugdatabase.com Accessed 04/11/26.
  5. Sanford Guide [online]. Amoxicillin. Last updated 24/9/26. Accessed via https://webedition.sanfordguide.com. Accessed 04/11/26.
  6. GIG Cymru NHS Wales. All Wales antimicrobial dosing in extremes of body weight in adults. Last updated April 2022. Accessed via https://phw.nhs.wales/resources/all-wales-antimicrobial-dosing-in-extremes-of-body-weight-in-adults/ Accessed 24/10/26.

Editorial Information

Last reviewed: 04 Nov 2026

Next review date: 31 Oct 2029

Author(s): AMST.