Aztreonam

General Information

Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.

Restricted formulary antimicrobial: For details see OUH netFormulary

AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.

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Renal impairment

eGFR (mL/min/1.73m²)	Dose
More than 30	Dose as in normal renal function
10-30	1-2g loading dose; then maintenance should be half of the normal dose
Less than 10	1-2g loading dose; then maintenance should be quarter of the normal dose
HD/HDF/High Flux	Dose as in eGFR less than 10ml/min/1.73m². Dialysed; give after dialysis
PD	Dose as in eGFR less than 10ml/min/1.73m². Not dialysed.

Hepatic impairment

Use with caution and monitor liver function.
A dose reduction of 20-25% is recommended for long-term treatment of patients with chronic liver disease with cirrhosis, especially in cases of alcoholic cirrhosis and when renal function is also impaired.

Pregnancy

Aztreonam is contraindicated in pregnancy as it enters the foetal circulation.

Breastfeeding

The amount of drug in breastmilk is probably too small to be harmful

Summary of Product Characteristics (SPC) for Azactam 1g Powder for Solution for Injection or Infusion Accessed via www.medicines.org.uk 26/03/18. Last updated 22/11/17
The Renal Drug Database. Aztreonam. Accessed via renaldrugdatabase.com 26/03/18. Last updated 20/02/18
BNF online accessed via www.medicinescomplete.com 19/12/18