Aztreonam with avibactam
General Information
Monobactam and beta-lactamase inhibitor antibiotic
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Reserve'. All indications to be discussed with Micro/ID.
Renal and hepatic impairment
Renal impairment
|
Creatinine Clearance (mL/min)* |
Dose |
Frequency |
|
|
Loading |
Maintenance |
||
|
51 or over |
2.7g (2g aztreonam / 677mg avibactam) |
2g (1.5g aztreonam / 500mg avibactam) |
every 6 hours |
|
30 - 50 |
2.7g (2g aztreonam / 677mg avibactam) |
1g (750mg aztreonam / 250mg avibactam) |
every 6 hours |
|
16 - 29 |
1.8g (1.35g aztreonam / 450mg avibactam) |
900mg (675mg aztreonam / 225mg avibactam) |
every 8 hours |
|
15 or less and on HD/HDF/High flux or PD**
HD/HDF/High flux: Dialysed; give post-dialysis on dialysis days PD: Not dialysed |
1.3g (1g aztreonam / 333mg avibactam) |
900mg (675mg aztreonam / 225mg avibactam) |
every 12 hours |
*dose ranges use creatinine clearance, rather than eGFR
** Aztreonam-avibactam should not be used in patients with CrCL 15mL/min or less unless haemodialysis or another form of renal replacement therapy is initiated.
Hepatic impairment
No dose adjustment required.
Dosing in obesity
No dose adjustment required.
Notable interactions
Please see the BNF, Summary of Product Characteristics or speak to a pharmacist.
Pregnancy and breastfeeding
Pregnancy
Limited or no data for use in pregnant women. Avoid unless benefit to mother outweighs risk to the child. Discuss with Micro/ID and pharmacy.
Breastfeeding
Discuss with pharmacy.
Additional information
Aztreonam and Avibactam 2g vial contains 1.5g Aztreonam & 0.5g Avibactam powder for concentrate for solution for infusion
References
- Pfizer Limited. Summary of Product Characteristics (SPC). Emblaveo 1.5 g/0.5 g powder for concentrate for solution for infusion. Last revision of the text: 03/2025. Accessed via www.medicines.org.uk Accessed 08/09/2025
- BNF online accessed via www.medicinescomplete.com Accessed 08/09/2025
- The Renal Drug Database. EMBLAVEO (aztreonam/avibactam sodium). [online]. Last updated: 27/05/2025. Accessed via https://renaldrugdatabase.com Accessed 08/09/2025