Cefepime with enmetazobactam (Exblifep®)
General Information
A cephalosporin and beta-lactamase inhibitor.
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: All indications to be discussed with Micro/ID. Has not been classified in 2025 UK modified AWaRe list.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF.
Standard dose
| Intravenous dose | |
| Standard dose |
2.5g (2g cefepime/0.5g enmetazobactam) TDS |
- Each vial contains 2g cefepime + 0.5g enmetazobactam
- Standard dose of 2.5g (2 g cefepime + 0.5g enmetazobactam) is 1 vial
Note: The duration of infusion varies with indication, see SPC.
Renal and hepatic impairment
Renal impairment
|
Dose |
Frequency |
|
|
Where creatinine clearance is over 150 ml/minute (augmented renal clearance), give infusion over 4 hours. |
Dose as in normal renal function | |
|
30-59 |
1.25 g
(1g cefepime/ 250 mg enmetazobactam)
|
TDS |
|
15-29 |
1.25 g
(1g cefepime/ 250 mg enmetazobactam)
|
BD |
|
Less than 15 |
1.25 g
(1g cefepime/ 250 mg enmetazobactam)
|
OD |
|
HD/HDF/High flux/PD |
Discuss with pharmacy |
|
*Dose ranges use creatinine clearance, rather than eGFR
Hepatic impairment
No dose adjustment required
References
- ADVANZ Pharma. EXBLIFEP 2 g/0.5 g powder for concentrate for solution for infusion summary of product characteristics. Electronic Medicines Compendium. Last revision of the text: 4/4/24 Available at https://www.medicines.org.uk/emc Accessed: 2/3/26
- British National Formulary. Cefepime-Enmetazobactam. Accessed via: BNF online accessed via www.medicinescomplete.com. Accessed 2/3/26
- Sanford Guide [online]. Cefepime-Enmetazobactam. Last updated 31/10/25. Accessed 2/3/26
- The Renal Drug Database. EXBLIFEP (cefepime hydrochloride and enmetazobactam). Last reviewed: 19/06/25. Available at: https://www.renaldrugdatabase.com Accessed 2/3/26