Adult
Cefotaxime
Warning
General Information
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Formulary antimicrobial: Use in accordance with Trust guidelines
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
Renal and hepatic impairment
Renal impairment
|
eGFR (mL/min/1.73m2) |
Dose |
|
More than 5 |
Dose as in normal renal function |
|
Less than 5 |
Initial dose of 1g then use half normal dose |
|
HD/HDF/High Flux |
Dose as in eGFR less than 5ml/min/1.73m2. Dialysed; give after dialysis |
|
PD |
Dose as in eGFR less than 5ml/min/1.73m2. Not dialysed |
Hepatic impairment
- Use with caution in patients with hepatic impairment.
- Reduce dose further if concurrent hepatic and renal failure.
Pregnancy and breastfeeding
Pregnancy
Not known to be harmful in pregnancy.
Breastfeeding
Present in low concentrations in breast milk, but appropriate to use.
References
- Summary of Product Characteristics (SPC) for Cefotaxime 1g powder for solution for injection vials. Accessed via www.medicines.org.uk 26/03/18. Last updated 11/12/17
- The Renal Drug Database. Cefotaxime. Accessed via renaldrugdatabase.com 26/03/18. Last updated 3/5/2018
- BNF online accessed via www.medicinescomplete.com 24/12/18