Adult
Cefoxitin
Warning
General Information
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance (ml/min) |
Dose |
|
30-80 |
1-2g every 8-12 hours |
|
10-29 |
1-2g every 12-24 hours |
|
5-10 |
500mg – 1g every 12-24 hours |
|
Less than 5 |
500mg -1g every 24-48 hours |
|
HD/HDF |
Dose as in creatinine clearance less than 5ml/min. Dialysed; give after dialysis. |
Note: dose ranges use creatinine clearance, rather than eGFR.
Hepatic impairment
No dose adjustment required
Pregnancy and breastfeeding
Pregnancy
Use only if benefits outweigh the risks
Breastfeeding
Discuss with pharmacy
References
- Summary of Product Characteristics (SPC) for Cefoxitin Sodium Powder for Injection. Accessed via http://www.medsafe.govt.nz/profs/Datasheet/h/hospiracefoxitinsodiuminj.pdf 26/03/18. Last updated 22/02/17