Ceftazidime
General Information
Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.
Note: If patient is over 80 years of age the usual daily maximum dose is 3g; this can be increased to 6g daily on advice documented by Micro/ID Consultant.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
Renal and hepatic impairment
Renal impairment
|
Creatinine clearance (ml/min) |
Maintenance dose |
|
31 - 50 |
1g-2g BD (over 80 years usual daily maximum of 3g) |
|
16-30 |
1g-2g OD |
|
6-15 |
500mg-1g OD |
|
Less than 5 |
500mg-1g every 48 hours |
|
HD |
Dose as in creatinine clearance less than 5ml/min. Dialysed; give after dialysis |
|
HDF/High Flux |
500mg-2g every 48 hours. Dialysed; give after dialysis |
|
PD |
500mg-1g every 24 hours. Dialysed; give after dialysis |
Note: dose ranges use creatinine clearance, rather than eGFR.
Hepatic impairment
Caution in severe hepatic impairment.
Pregnancy and breastfeeding
Pregnancy
Only use in pregnancy if benefits outweigh the risks
Breastfeeding
Safe to use during breastfeeding
References
- Summary of Product Characteristics (SPC) for Ceftazidime 1g Powder for solution for Injection. Accessed via www.medicines.org.uk 26/03/18. Last updated 03/11/17
- The Renal Drug Database. Ceftazidime. Accessed via renaldrugdatabase.com 26/03/18. Last updated 3/5/18
- Drugs in Pregnancy and Lactation. Briggs G et al. 6th Edition.