Cefuroxime

General Information

Do NOT use if patient has a history of severe penicillin allergy. If in doubt, discuss with Micro/ID.

Restricted formulary antimicrobial: For details see OUH netFormulary

AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.

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Renal impairment

eGFR (mL/min/1.73m²)	IV Dose
More than 20	Dose as in normal renal function
10-20	750mg-1.5g every 12 hours
Less than 10	750mg-1.5g every 24 hours
HD/HDF/High Flux/PD	Dose as in eGFR less than 10ml/min/1.73m². Dialysed; give after dialysis

Hepatic impairment
No dose adjustment required

Pregnancy

Not known to be harmful

Breastfeeding

Present in milk in low concentration but appropriate to use

Only IV cefuroxime is on the OUHFT Formulary.

Summary of Product Characteristics (SPC) for Cefuroxime 1.5g Powder for solution for Injection or Infusion. Accessed via www.medicines.org.uk 26/03/18. Last updated 13/06/14
The Renal Drug Database. Cefuroxime. Accessed via renaldrugdatabase.com 26/03/18. Last updated 21/12/17
Drugs in Pregnancy and Lactation. Briggs G et al. 6^th Edition.