Adult
Cycloserine
Warning
General Information
Restricted formulary antimicrobial: For details see OUH netFormulary
Renal and hepatic impairment
Renal impairment
|
Creatinine Clearance (ml/min) |
Oral Dose |
|
10-50 |
250mg-500mg every 24 hours. Monitor blood levels weekly |
|
Less than 10 |
250mg-500mg every 36-48 hours. Monitor blood levels weekly. |
| HD/HDF/High Flux | Dose as in creatinine clearance less than 10ml/min. Dialysed; give after dialysis |
| PD | Dose as in creatinine clearance less than 10ml/min. Unknown dialysability |
Note: dose ranges use creatinine clearance, rather than eGFR.
Hepatic impairment
No dose adjustment required but monitor hepatic function during treatment.
Pregnancy and breastfeeding
Pregnancy
Use only if potential benefit outweighs risk.
Breastfeeding
Discuss with pharmacy.
Additional information
Cycloserine levels should be monitored in all patients, especially in those with renal impairment or if dose exceeds 500 mg daily or if signs of toxicity. Cycloserine level should not exceed 35 mg/L.
References
- Summary of Product Characteristics (SPC) for Cycloserine. Accessed via www.medicines.org.uk 26/03/18. Last updated 07/02/18
- The Renal Drug Database. Cycloserine. Accessed via renaldrugdatabase.com 26/03/18. Last updated 20/02/18
- Drugs in Pregnancy and Lactation. Briggs G et al. 6th Edition.