Dapsone

General Information

Restricted formulary antimicrobial: For details see OUH netFormulary

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Renal impairment

Creatinine clearance (mL/min)	Dose
20-50	Dose as in normal renal function
10-20	Dose as in normal renal function. Use with caution.
Less than 10	50-100mg daily. Use with caution. No dose reduction is required for malaria prophylaxis.
HD/HDF/High Flux	Dose as in creatinine clearance less than 10ml/min. Dialysed; give after dialysis.
PD	Dose as in creatinine clearance less than 10ml/min. Likely dialysability.

Note: dose ranges use creatinine clearance, rather than eGFR.

Hepatic impairment

Dosage should be reduced in the elderly where there is an impairment of hepatic function.

Pregnancy

Use only if potential benefit outweighs risk. Consider giving folic acid 5mg daily throughout pregnancy.

Breastfeeding

Discuss with pharmacy. Risk of haemolytic anaemia; although significant amount in milk, risk to infant very small unless infant is G6PD deficient.

Patients with G6PD deficiency more susceptible to haemolysis.
Counsel patients on long term treatment to recognise signs and symptoms of blood disorders.
Regular blood counts are recommended in patients with severe anaemia or renal impairment: weekly for the 1st month, then monthly for 6 months, then semi-annually.

Summary of Product Characteristics (SPC) for Dapsone tablets 100mg. Accessed via www.medicines.org.uk 26/03/18. Last updated 18/01/16
The Renal Drug Database. Dapsone. Accessed via renaldrugdatabase.com 26/03/18. Last updated 06/11/17
Drugs in Pregnancy and Lactation. Briggs G et al. 6^th Edition.