Ethambutol
General Information
Restricted formulary antimicrobial: For details see OUH netFormulary
Renal and hepatic impairment
Renal impairment
|
Creatinine Clearance (mL/min) |
Oral Dose |
|
More than 20 |
Dose as in normal renal function |
|
10-20 |
15mg/kg every 24-36 hours, or 7.5-15mg/kg/day |
|
Less than 10 |
15mg/kg every 48 hours, or 5-7.5mg/kg/day |
|
HD/HDF/High Flux |
Dose as in creatinine clearance less than 10ml/min. Dialysed; give after dialysis |
|
PD |
Dose as in creatinine clearance less than 10ml/min. Not dialysed |
Note: dose ranges use creatinine clearance, rather than eGFR.
Monitor plasma ethambutol concentration in patients with renal impairment.
Hepatic impairment
No dose adjustment required.
Pregnancy and breastfeeding
Not known to be harmful. Use if potential benefit outweighs risk.
Additional information
Test visual acuity before treatment and warn patients to report visual changes.
References
- Summary of Product Characteristics (SPC) for Ethambutol 100mg tablets. Accessed via www.medicines.org.uk 26/03/18. Last updated 19/01/17
- The Renal Drug Database. Ethambutol. Accessed via renaldrugdatabase.com 26/03/18. Last updated 21/12/17