Adult
Foscarnet
Warning
General Information
Restricted formulary antimicrobial: For details see OUH netFormulary
Renal and hepatic impairment
Renal impairment
| Creatinine clearance (mL/min) | Dose |
| 20-50 | 28mg/kg every 8 hours |
| 10-20 | 15mg/kg every 8 hours |
| less than 10 |
6mg/kg every 8 hours |
| HD/ HDF/High Flux/PD |
Dose as in creatinine clearance less than 10ml/min. Dialysed; give after dialysis. |
Note: dose ranges use creatinine clearance, rather than eGFR.
Hepatic impairment
No dose adjustment required in hepatic impairment.
Pregnancy and breastfeeding
Pregnancy
Discuss with pharmacy
Breastfeeding
Discuss with pharmacy.
Additional information
- Risk of renal toxicity – ensure adequate hydration and monitor renal function closely.
- Monitor serum calcium and magnesium
- Foscarnet comes as a 24mg/ml solution – round dose to nearest measurable quantity
References
- Summary of Product Characteristics (SPC) for Foscavir 24mg/ml Solution for Infusion. Accessed via www.medicines.org.uk 26/03/18. Last updated 05/10/17
- The Renal Drug Database. Flucytosine. Accessed via renaldrugdatabase.com 26/03/18. Last updated 21/12/17