Gentamicin - Infective Endocarditis Monitoring | Oxford University Hospitals NHS Foundation Trust

General Information

Formulary antimicrobial: Use in accordance with Trust guidelines

AWaRe antibiotic classification: 'Access'. Use as per guidelines.

This guide relates to synergistic gentamicin 3mg/kg once daily dosing for infective endocarditis. For other gentamicin monitoring see HERE

Auditory function may be affected. Please refer to Audiometry and intravenous aminoglycosides.

Open all

When to take levels:

Creatinine clearance 30mL/min and over: Check trough levels prior to day 3 administration.
Creatinine clearance less than 30mL/min: Check trough levels prior to day 2 administration and wait for level. Do not redose until the level is less than 1mg/L

Levels and action to take:

Target level: Trough level less than 1mg/L

Discuss levels over 1mg/L with Micro/ID or pharmacy as dose adjustments may be required.

Frequency of monitoring:

For patient with stable renal function and trough level less than 1mg/L: Three times a week.
For patient with creatine clearance less than 30ml/min or unstable renal function or trough level more than 1mg/L: Daily level