Adult
Isoniazid
Warning
General Information
Tablets and Liquid are Restricted formulary antimicrobials: For details see OUH netFormulary
Injection is Unlicensed Restricted formulary antimicrobial: For details see OUH netFormulary
Renal and hepatic impairment
Renal impairment
| eGFR (mL/min/1.73m2) | Dose |
| More than 10 | Dose as in normal renal function |
| Less than 10 | 200-300mg OD |
| HD/HDF/High Flux/PD |
Dose as in eGFR less than 10ml/min/1.73m2. Dialysed; give after dialysis |
- Risk of ototoxicity and peripheral neuropathy enhanced in renal impairment. Ensure pyridoxine is prescribed.
Hepatic impairment
- Use with caution in hepatic impairment.
- Monitor liver function regularly, particularly in first 2 months of treatment.
Pregnancy and breastfeeding
Pregnancy
Not known to be harmful in pregnancy; ensure prophylactic pyridoxine is prescribed.
Breastfeeding
Discuss with pharmacy. Theoretical risk of convulsions and neuropathy in breastfed infant; prophylactic pyridoxine advisable in mother
Additional information
Risk of severe hepatitis. Advise all patients and/or their carers to recognise signs of liver disorder.
References
- Summary of Product Characteristics (SPC) for Isoniazid. Accessed via www.medicines.org.uk 26/03/18. Last updated 14/09/15
- The Renal Drug Database. Isoniazid. Accessed via renaldrugdatabase.com 26/03/18. Last updated 07/09/17
- Drugs in Pregnancy and Lactation. Briggs G et al. 6th Edition.