Adult
Micafungin
Warning
General Information
Restricted formulary antimicrobial: For details see OUH netFormulary
Renal and hepatic impairment
Renal impairment
No dose adjustment necessary
HD/HDF/High Flux/PD - Dose as in normal renal function. Not dialysed.
Hepatic impairment
- Risk of potentially life threatening hepatotoxicity
- Use with caution in mild to moderate hepatic impairment (no dose adjustment necessary)
- Avoid in severe hepatic impairment.
Pregnancy and breastfeeding
Discuss with pharmacy. Use only if potential benefit outweighs the risk (toxicity in animal studies)
Additional information
Potentially life-threatening hepatotoxicity reported. Monitor liver function in all patients —discontinue if significant and persistent abnormalities in liver function tests develop.
References
- Summary of Product Characteristics (SPC) for Mycamine 100mg powder for solution for infusion. Accessed via www.medicines.org.uk 26/03/18. Last updated 05/03/18
- The Renal Drug Database. Micafungin. Accessed via renaldrugdatabase.com 26/03/18. Last updated 13/11/17
- BNF online accessed via www.medicinescomplete.com 4/1/19; last updated 11/12/18