Nitazoxanide

Nitroimidazole resistant giardiasis: 500mg po bd for 3 days with food

Eradication of intraluminal Entamoeba histolytica cysts: 500mg po bd for 3 days with food

Refractory diarrhoea caused by Cryptosporidium species in immunocompetent adults: 500mg po bd po for 3 days with food

Renal impairment

No dose adjustment necessary

Hepatic impairment

No dose adjustment necessary

• Sanford guide says use with caution but not stated in other resources.

Pregnancy 

Discuss with pharmacy

Breastfeeding

Discuss with pharmacy

• Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (more than 99.9%) therefore may interact with other highly plasma protein-bound drugs with narrow therapeutic window, such as warfarin, phenytoin or digoxin. Therapeutic drug monitoring may be needed in certain cases. Monitor for adverse reactions.
• Food enhances the bioavailability of the pharmacologically active metabolite tizoxanide. Nitazoxanide should be taken just after eating food. Do not take it on an empty stomach.

This is not a complete list. Please see the Summary of Product Characteristics or speak to a pharmacist.

• Avoid alcohol when taking nitazoxanide.