Adult
Oxytetracycline
General Information
Formulary antimicrobial: Use in accordance with Trust guidelines
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
Renal and hepatic impairment
Renal impairment
Use with caution in renal impairment as tetracycline antibiotics may exacerbate renal failure.
|
eGFR (mL/min/1.73m2) |
Oral dose |
|
More than 10 |
Dose as in normal renal function |
|
Less than 10 |
250mg QDS |
|
HD/PD |
Dose as in eGFR less than 10ml/min/1.73m2. Not dialysed |
|
HDF/High Flux |
Dose as in eGFR less than 10ml/min/1.73m2. Unknown dialysability |
Hepatic impairment
Contra-indicated in chronic hepatic dysfunction. Use with caution in patients who are also receiving potentially hepatotoxic drugs.
Pregnancy and breastfeeding
Avoid in pregnancy and breastfeeding
References
- Summary of Product Characteristics (SPC) for Oxytetracycline Tablets BP 250mg. Accessed via www.medicines.org.uk 26/03/18. Last updated 20/03/13
- The Renal Drug Database. Oxytetracycline. Accessed via renaldrugdatabase.com 26/03/18. Last updated 21/11/17
- BNF online accessed via www.medicinescomplete.com 8/1/19; last updated 14/11/18