Piperacillin-Tazobactam
General Information
Anti-pseudomonal penicillin and beta-lactamase inhibitor. Do NOT use if patient is allergic to penicillin.
For adult critical care areas only: Where using piperacillin-tazobactam by continuous infusion see Adult Intensive Care Medication Guidelines
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Watch'. Use as per guidelines. All other indications to be discussed with Micro/ID.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Dosing
|
|
Intravenous piperacillin-tazobactam |
|
Standard dose |
4.5g TDS* |
|
Pseudomonas or neutropenic sepsis |
4.5g QDS or 4.5g TDS extended infusion (over 3-4 hours) |
|
Elastomeric device |
13.5g over 24hrs |
*consider 4.5g QDS in obese patients, depending on renal function
Renal and hepatic impairment
Renal Impairment
|
eGFR (mL/min/1.73m2) |
piperacillin-tazobactam dose |
|
40 and over |
No dose adjustment |
|
20-40 |
Max 4.5g TDS |
|
Less than 20 |
Max 4.5g BD |
|
HD/HDF/High Flux |
Max 4.5g BD. Dialysed; give after dialysis |
|
PD |
Max 4.5g BD. Not dialysed |
Hepatic impairment
No dose adjustment required in hepatic impairment.
References
- Piperacillin/Tazobactam 4 g/0.5 g powder for solution for infusion [online]. Manufacturer - Esteve Pharmaceuticals (formerly Intrapharm Laboratories) – last updated: 2022 Mar. Accessed via: www.emc.medicines.org.uk [Accessed 2023 Sep 6].
- The Renal Drug Database. Tazocin (Piperacillin/tazobactam) - last updated: 2019 Sep 9. Accessed via: https://renaldrugdatabase.com [Accessed 2023 Sep 6].
- UK Medicines Information. How should antibiotics be doses in obesity – last updated 2017 Mar 1. Accessed via: https://www.gloshospitals.nhs.uk/media/documents/Obese_Dosing_2016_update.pdf [Accessed 21/9/23].