Adult
Pivmecillinam
Warning
General Information
A penicillin antibiotic. Do NOT use if patient is allergic to penicillin.
Restricted formulary antimicrobial: For details see OUH netFormulary
AWaRe antibiotic classification: 'Access'. Use as per guidelines.
For all information regarding interactions, contraception, pregnancy and breastfeeding and additional information, see BNF and Summary of Product Characteristics (SPC).
Standard dose
400mg po STAT then 8 hours later 200mg tds
Obesity
No dose adjustment required
Renal and hepatic impairment
Renal impairment
Dose adjustment is not necessary in impaired renal function.
If using for extended periods of time: Accumulation may occur in patients with severe renal impairment. Discuss with Micro/ID about the need to use a lower dose.
Hepatic impairment
Dose adjustment not necessary
References
- Aurobindo Pharma - Milpharm Ltd. Pivmecillinam 200mg film-coated tablets summary of product characteristics: Electronic Medicines Compendium [Internet]. Last revision of the text: 26/10/2023. Accessed 14/12/23 from https://www.medicines.org.uk/emc/product/4982/smpc
- Karo Pharma AB. Selexid Tablets summary of product characteristics: Electronic Medicines Compendium [Internet]. Last revision of the text: 07/03/2023. Accessed 14/12/23 from https://www.medicines.org.uk/emc/product/3799/smp
- Joint Formulary Committee. British National Formulary (BNF). 27 September 2023 [Internet]. .Accessed 14/12/23 fromhttps://www.medicinescomplete.com
- Meng L, Mui E, Ha DR, Stave C, Deresinski SC, Holubar M. Comprehensive guidance for antibiotic dosing in obese adults: 2022 update. Pharmacotherapy. 2023; 43(3):226-46
- The Renal Drug Database. Pivmecillinam Hydrochloride [Internet]. Revision date 22/5/23. Accessed 14/12/23 at: https://renaldrugdatabase.com/monographs/pivmecillinam-hydrochloride