Adult
Pyrimethamine
Warning
General Information
Restricted formulary antimicrobial: For details see OUH netFormulary
Renal and hepatic impairment
Renal impairment
No dose adjustment necessary in renal impairment
Hepatic impairment
Manufacturer advises caution in hepatic impairment
Pregnancy and breastfeeding
Pregnancy
Theoretical teratogenic risk in first trimester (folate antagonist) – should be avoided unless the benefits outweigh the risks of treatment
Breastfeeding
Discuss with pharmacy.
Additional information
Monitor full blood count on prolonged treatment
References
- Summary of product characteristics for Daraprim tablets (GlaxoSmithKline UK). Accessed via www.medicines.org.uk 14/1/19; last updated 4/1/18
- BNF online accessed via www.medicinescomplete.com 14/1/19; last updated 11/12/18