Trimethoprim
General Information
Formulary antimicrobial: Use in accordance with Trust guidelines
AWaRe antibiotic classification: 'Access'. Use as per guidelines.
Standard dose
|
oral Trimethoprim |
|
| Treatment dose | 200mg po bd |
| Prophylaxis dose |
100mg po on Alternatively 200 mg for 1 dose, dose to be taken following exposure to a trigger. |
Obesity
No dose adjustment required in obesity.
Renal and hepatic impairment
Renal impairment
|
eGFR (mL/min/1.73m2) |
trimethoprim dose |
|
15 or more |
Dose as in normal renal function |
|
Less than 15 |
50 - 100% of normal dose |
|
HD/HDF/High Flux/PD |
Dose as in eGFR less than 15mL/min/1.73m2 HD/HDF/High Flux: Dialysed; give after dialysis |
Note: The reference for this dosing information is Renal Drug Database and dosing is different to those in BNF and Summary of Product Characteristics.
Hepatic impairment
Avoid in severe hepatic impairment.
Pregnancy and breastfeeding
Pregnancy: Contraindicated in pregnancy; teratogenic risk in the first trimester.
Breastfeeding: Present in breastmilk – short term use not known to be harmful
References
- Accord Healthcare Limited. Summary of Product Characteristics (SPC) for Trimethoprim 200mg Tablets. Last updated 14 October 2024. Accessed via MHRA Products | Product results on 23rd December 2024.
- The Renal Drug Database. Trimethoprim. Last updated 13/02/2024 Accessed via renaldrugdatabase.com on 23rd December 2024.
- National Institute for Health and Care Excellence (NICE ) CKS. Urinary tract infection (lower) - women: Trimethoprim. Last updated December 2024 Accessed via Trimethoprim | Prescribing information | Urinary tract infection (lower) - women | CKS | NICE on 23/12/24.
- Black D. Obesity Dosing Adjustments - Sanford Web Guide [Internet]. Last updated 17/12//24. Available from: https://web.sanfordguide.com/en/comparisons-1/drug-usage-dosing/obesity-dosing-adjustments Accessed 2/1/25