Valaciclovir

Renal impairment

For CMV prophylaxis only (post solid organ transplant):

Note: dose ranges use creatinine clearance, rather than eGFR.

(from Oxford Transplant Centre Virus Management module available at  http://ouh.oxnet.nhs.uk/RTU/Pages/OxfordTransplantCentre.aspx)

For other indications:

For renal dosing in other indications, please refer to product literature and discuss with a pharmacist.

Hepatic impairment

Use high doses with caution in patients with severe hepatic disease.

Pregnancy

Use only if potential benefits outweigh the risks

Breastfeeding

Discuss with pharmacy.

• Ensure patients have adequate fluid intake whilst on valaciclovir.
• Valaciclovir is only available by the oral route (as a tablet only).

1. Summary of Product Characteristics (SPC) for Valaciclovir 500mg Tablets. Accessed via www.medicines.org.uk 26/03/18. Last updated 13/02/2009
2. BNF online accessed via www.medicinescomplete.com 15/1/19; last updated 11/12/18
3. OUH clinical guideline: virus management in solid organ transplant recipients and islet cell transplant recipients v 3.1; valid from April 2019