AHAH: Skin & Soft Tissue Infections | Oxford University Hospitals NHS Foundation Trust

Oxford University Hospitals NHS Foundation Trust
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AHAH: Skin & Soft Tissue Infections

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Duration: 5 days

Antibiotic Regimens:

Route	Antibiotic and Dosage	Notes
Oral (Preferred)	flucloxacillin 1g po QDS
	cefalexin 1g po TDS
	co-trimoxazole 960mg po BD	Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics
	doxycycline 100mg po BD	Can also be 200mg po OD
IV (Aim for rapid oral switch)	cefazolin 2g iv OD AND probenecid 1g po OD	Probenecid is taken orally just before cefazolin is given. Be aware of interactions and dose adjustment in renal impairment
IV (Aim for rapid oral switch)	Discuss with Micro/ID	Options recommended by Micro/ID may include linezolid, teicoplanin, daptomycin or dalbavancin.

Consider referral to OCDEM for MDT discussion on management.

Duration: 5 days

Antibiotic Regimens:

Mild infection

Route	Antibiotic and Dosage	Notes
Oral (Preferred)	flucloxacillin 1g po QDS
	doxycycline 100mg po BD	Can also be 200mg po OD
	co-trimoxazole 960mg po BD	Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics

Moderate infection

Route	Antibiotic and Dosage	Notes
Oral (Preferred)	co-trimoxazole 960mg po BD AND metronidazole 400mg po TDS	Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics
	doxycycline 100mg BD AND metronidazole 400mg po TDS	Doxycycline can also be 200mg po OD
	co-amoxiclav 625mg po TDS	Avoid in patients with high frailty scores
IV (Aim for rapid oral switch)	co-trimoxazole 960mg iv BD AND metronidazole 400mg po TDS	Pause ACE inhibitors/Angiotensin receptor blockers or Potassium sparing diuretics Metronidazole is oral
IV (Aim for rapid oral switch)	co-amoxiclav 1.2g iv TDS	Avoid in patients with high frailty scores

Severe infection

Refer to inpatient guidelines.