Adult

Diabetic Foot Infection, Mild

Warning

It is essential that cases of mild diabetic foot infection are managed in conjunction with Podiatry. An assessment of vascular sufficiency should be performed. Refer to OUH Acute Foot Pathway (Acute Foot Pathway)

 

Mild diabetic foot infection is defined as: 2 or more of the following

  • local swelling or induration
  • erythema (less than 2cm around ulcer)
  • local tenderness or pain
  • local warmth
  • purulent discharge

A wound sample should be taken prior to/as soon as possible after starting antibiotics. Superficial swabs have limited diagnostic value, so preference should be made for a deep swab, collection of pus, tissue sample (by an appropriately trained clinician) or surgical cultures.

Cases are typically treated with oral antibiotics for 7 days.

Review empirical treatment within 48-72 hours

Preferred

flucloxacillin 500mg - 1g po qds

Alternative

For penicillin allergy (non-severe and severe) and/or for MRSA positive patients: 

doxycycline 100mg po bd

OR

co-trimoxazole 960mg po bd

 

For pregnant patients:

erythromycin 500mg po qds

Editorial Information

Last reviewed: 27 Oct 2026

Next review date: 19 Oct 2029

Author(s): AMST.