Adult

Soft tissue injury, contaminated

For skin and soft tissue wounds that are contaminated but not actively infected. 

  • Thorough cleaning and/or surgical debridement is indicated. 
  • Tetanus risk assessment should be performed. See also Tetanus prone wounds.

Suggested duration of antibiotic therapy

  • Consider antibiotics for 3 days where heavy contamination has occurred, especially with soil, mud, faeces, and dirty water. 
  • Consider antibiotics for 5 days where a foreign body has been removed from a contaminated wound. 
  • When a foreign body cannot be removed, consult Micro/ID

Preferred

flucloxacillin 1g po or iv qds PLUS metronidazole 400mg po tds 

Alternative

Penicillin allergy (non-severe and severe) and MRSA positive patients: 

co-trimoxazole 960mg po bd

OR

doxycycline 100mg po bd PLUS metronidazole 400mg po tds

 

Consider penicillin allergy assessment and delabelling 

Editorial Information

Last reviewed: 01 Apr 2024