Trauma and Orthopaedics
Link to General Principles, including redosing table
Trauma and Orthopaedic Surgery
Preferred (including for penicillin allergy (non-severe)): cefazolin iv (see dosing table below)
cefazolin iv dose | |
Weight under 50kg | 1g |
Weight 50kg to less than 120kg | 2g |
Weight 120kg or more | 3g |
Creatinine Clearance less than 10ml/min or patient receiving Haemodialysis | 1g |
For penicillin allergy (severe) and/ or MRSA positive patients: teicoplanin 800mg iv
Prosthetic Joint Hip and Knee Surgery
Preferred (including for penicillin allergy (non-severe)): cefazolin iv (see dosing table below) AND gentamicin 3mg/kg iv
cefazolin iv dose | |
Weight under 50kg | 1g |
Weight 50kg to less than 120kg | 2g |
Weight 120kg or more | 3g |
Creatinine Clearance less than 10ml/min or patient receiving Haemodialysis | 1g |
For penicillin allergy (severe) and/or MRSA positive patient: gentamicin 3mg/kg iv AND teicoplanin 800mg iv
Revision Arthroplasty
Includes: suspected infection with 1 stage or 2 stage procedure, debridement and retention of infected prosthesis, retention and removal/manipulation of device with suspected infection.
Preferred (including MRSA positive patients): teicoplanin 800mg iv AND gentamicin 3mg/kg iv
Open fracture - initial debridement
Continue treatment antibiotics, see Open fracture treatment
Preferred (including for penicillin allergy (non-severe)): cefazolin iv (see dosing table below) AND gentamicin 3mg/kg iv
cefazolin iv dose | |
Weight under 50kg | 1g |
Weight 50kg to less than 120kg | 2g |
Weight 120kg or more | 3g |
Creatinine Clearance less than 10ml/min or patient receiving Haemodialysis | 1g |
For penicillin allergy (severe) or MRSA positive patients: teicoplanin 800mg iv AND gentamicin 3mg/kg iv
Open fracture - definitive skeletal stability/ definitive soft tissue coverage
Preferred (including for penicillin allergy (non-severe, severe) or MRSA positive patients):
teicoplanin 800mg iv (if more than 16 hours since last dose) AND gentamicin 3mg/kg iv
No further post-operative antibiotics required
Spinal Surgery
see Neurosurgery