Adult

Trauma and Orthopaedics

Link to General Principlesincluding redosing table

Trauma and Orthopaedic Surgery

Preferred (including for penicillin allergy (non-severe)): cefazolin iv (see dosing table below)

  cefazolin iv dose 
Weight under 50kg 1g
Weight 50kg to less than 120kg 2g
Weight 120kg or more 3g
Creatinine Clearance less than 10ml/min or patient receiving Haemodialysis 1g

For penicillin allergy (severe) and/ or MRSA positive patients:  teicoplanin 800mg iv

Prosthetic Joint Hip and Knee Surgery

Preferred (including for penicillin allergy (non-severe)): cefazolin iv (see dosing table below) AND  gentamicin 3mg/kg iv

  cefazolin iv dose 
Weight under 50kg 1g
Weight 50kg to less than 120kg 2g
Weight 120kg or more 3g
Creatinine Clearance less than 10ml/min or patient receiving Haemodialysis 1g

For penicillin allergy (severe) and/or MRSA positive patient: gentamicin 3mg/kg iv AND teicoplanin 800mg iv

Revision Arthroplasty

Includes: suspected infection with 1 stage or 2 stage procedure, debridement and retention of infected prosthesis, retention and removal/manipulation of device with suspected infection.

Preferred (including MRSA positive patients): teicoplanin 800mg iv AND gentamicin 3mg/kg iv

Open fracture - initial debridement

Continue treatment antibiotics, see Open fracture treatment

Preferred (including for penicillin allergy (non-severe)): cefazolin iv (see dosing table below) AND gentamicin 3mg/kg iv

  cefazolin iv dose 
Weight under 50kg 1g
Weight 50kg to less than 120kg 2g
Weight 120kg or more 3g
Creatinine Clearance less than 10ml/min or patient receiving Haemodialysis 1g

For penicillin allergy (severe) or MRSA positive patients: teicoplanin 800mg iv AND gentamicin 3mg/kg iv

Open fracture - definitive skeletal stability/ definitive soft tissue coverage

Preferred (including for penicillin allergy (non-severe, severe) or MRSA positive patients):

teicoplanin 800mg iv (if more than 16 hours since last dose) AND gentamicin 3mg/kg iv

No further post-operative antibiotics required

Spinal Surgery

see  Neurosurgery

Editorial Information

Last reviewed: 01 Feb 2024