Posaconazole (Noxafil): tablets and oral suspension are not directly interchangeable

MHRA Drug Safety Update September 2016

Switching from posaconazole oral solution to tablets has resulted in cases of dose-related toxicity, whereas switching from tablets to oral solution has resulted in underdosing and lack of efficacy.

Advice for healthcare professionals:

• posaconazole tablets and oral suspension are not directly interchangeable
• switching from oral suspension to tablets can lead to overdosing and serious adverse drug reactions, whereas switching from tablets to oral suspension can lead to underdosing and lack of efficacy
• prescribers should specify the dosage form for posaconazole on every prescription
• pharmacists should ensure that the correct oral form is dispensed to patients