Paediatric

Infected eczema (Bacterial, mild-moderate)

In people who are not systemically unwell, do not routinely offer either a topical or oral antibiotic for secondary bacterial infection of eczema. Take into account:

  • the evidence, which suggests a limited benefit with antibiotics in addition to topical corticosteroids compared with topical corticosteroids alone
  • the risk of antimicrobial resistance with repeated courses of antibiotics
  • the extent and severity of symptoms or signs
  • the risk of developing complications, which is higher in people with underlying conditions such as immunosuppression. 

Do not routinely take a skin swab for microbiological testing in people with secondary bacterial infection of eczema at the initial presentation.

Also prescribe emollient and topical steroids of appropriate potency (see OUH dermatology guideline). Eczema is often undertreated due to use of inappropriately low potency corticosteroids. Topical steroids are required to reduce inflammation especially if secondary infection is suspected.

Preferred

Topical (for localised infection only)

Fusidic acid 2% cream TDS for 5-7 days

Fusidic acid containing topical treatments should not be used for prolonged periods due to high chance of bacterial resistance.

 

Oral

flucloxacillin po (see dosing table) Treat for 5-7 days.

Age

flucloxacillin oral dose

1 month to 1 year

62.5-125mg QDS

2-9 years

125-250mg QDS

10-17 years

250-500mg QDS

 

For penicillin allergy (non-severe) or if flucloxacillin not tolerated:

cefalexin po (see dosing table). Treat for 5-7 days

Age

cefalexin oral dose

1 month to 11 months

125mg BD

1 year-4 years

125mg TDS

5-11 years

250mg TDS

12-17 years

500mg TDS

Alternative

For penicillin allergy (severe):

Under 6 months - Clarithromycin po (see dosing table). Treat for 5-7 days.

Weight

clarithromycin oral dose

Under 8 kg

7.5mg/kg BD

8-11 kg

62.5mg BD

12-19kg

125mg BD

For 6 months and over - azithromycin 10mg/kg (max 500mg per dose) po OD. Treat for 3 days.

For worsening symptoms or if MRSA positive

6 weeks or older:  co-trimoxazole po (see dosing table). Treat for 5-7 days.

Age co-trimoxazole oral dose
6 Weeks to 5 Months 120mg BD
6 Months to 5 Years 240mg BD

6 Years to 11 years

480mg BD

12 years to 17 years 960mg BD

Editorial Information

Last reviewed: 01 Aug 2021

Author(s): AMST.

Approved By: MMTC