Infected eczema (Bacterial, mild-moderate)
In people who are not systemically unwell, do not routinely offer either a topical or oral antibiotic for secondary bacterial infection of eczema. Take into account:
- the evidence, which suggests a limited benefit with antibiotics in addition to topical corticosteroids compared with topical corticosteroids alone
- the risk of antimicrobial resistance with repeated courses of antibiotics
- the extent and severity of symptoms or signs
- the risk of developing complications, which is higher in people with underlying conditions such as immunosuppression.
Do not routinely take a skin swab for microbiological testing in people with secondary bacterial infection of eczema at the initial presentation.
Also prescribe emollient and topical steroids of appropriate potency (see OUH dermatology guideline). Eczema is often undertreated due to use of inappropriately low potency corticosteroids. Topical steroids are required to reduce inflammation especially if secondary infection is suspected.
Preferred
Topical (for localised infection only)
Fusidic acid 2% cream TDS for 5-7 days
Fusidic acid containing topical treatments should not be used for prolonged periods due to high chance of bacterial resistance.
Oral
flucloxacillin po (see dosing table) Treat for 5-7 days.
Age |
flucloxacillin oral dose |
1 month to 1 year |
62.5-125mg QDS |
2-9 years |
125-250mg QDS |
10-17 years |
250-500mg QDS |
For penicillin allergy (non-severe) or if flucloxacillin not tolerated:
cefalexin po (see dosing table). Treat for 5-7 days
Age |
cefalexin oral dose |
1 month to 11 months |
125mg BD |
1 year-4 years |
125mg TDS |
5-11 years |
250mg TDS |
12-17 years |
500mg TDS |
Alternative
For penicillin allergy (severe):
Under 6 months - Clarithromycin po (see dosing table). Treat for 5-7 days.
Weight |
clarithromycin oral dose |
Under 8 kg |
7.5mg/kg BD |
8-11 kg |
62.5mg BD |
12-19kg |
125mg BD |
For 6 months and over - azithromycin 10mg/kg (max 500mg per dose) po OD. Treat for 3 days.
For worsening symptoms or if MRSA positive
6 weeks or older: co-trimoxazole po (see dosing table). Treat for 5-7 days.
Age | co-trimoxazole oral dose |
6 Weeks to 5 Months | 120mg BD |
6 Months to 5 Years | 240mg BD |
6 Years to 11 years |
480mg BD |
12 years to 17 years | 960mg BD |