Tetanus-prone wounds
Thorough cleaning of wounds is essential.
A tetanus-prone wound includes:
- puncture-type injuries acquired in a contaminated environment and likely therefore to contain tetanus spores e.g. gardening injuries, needles in the community
- wounds containing foreign bodies such as wound splinters
- compound fractures
- wounds or burns with systemic sepsis
- certain animal bites and scratches - although smaller bites from domestic pets are generally puncture injuries, animal saliva should not contain tetanus spores unless the animal has been rooting in soil or lives in an agricultural setting. See also Bites, animal/human/insects
A high risk tetanus-prone wound is defined as a wound/burn with any one of the above criteria plus:
- heavy contamination with material likely to contain tetanus spores e.g. soil, manure
- wounds or burns that show extensive devitalised tissue
- wounds or burns that require surgical intervention that is delayed for more than six hours are high risk even if the contamination was not initially heavy.
Confirm the patient’s vaccine status. For further information about the NHS national vaccination schedule, see Complete routine immunisation schedule from 1 January 2025 - GOV.UK
Some groups of patients are considered “Not immunised or immunisation status unknown or uncertain”. These include:
- Injecting drug users where there is any doubt to their immunisation status. This group may be at high risk from tetanus-contaminated illicit drugs.
- Patients who are severely immunosuppressed, even if fully vaccinated in the past.
For those whose immunisation status is uncertain, a full course of immunisation is required.
Management of tetanus-prone wounds
The Green Book on Immunisation, Chapter 30: Tetanus provides recommendations about the management of tetanus prone wounds, see below:
Notes
Tetanus vaccine is to be given when “reinforcing” dose of vaccine is needed:
- Aged 2 months to 2 years: Infanrix-Hexa® 0.5mL IM once only.
- Aged 3 years to 9 years:
- If patient has not had primary vaccines: Infanrix-Hexa® 0.5mL IM once only.
- If patient has had primary vaccines but not booster: Repevax® 0.5mL IM once only.
- If Repevax® unavailable: Boostrix-IPV® 0.5mL IM once only.
- Over 10 years of age:
- If unvaccinated or partially vaccinated: Revaxis® 0.5mL IM once only.
Human tetanus immunoglobulin dosing:
- Prevention: 250 units by intramuscular injection (IM) or increase to 500 units IM if more than 24 hours since injury or risk of heavy contamination or following burns.
- Treatment: Discuss all cases of tetanus treatment with Micro/Paeds ID.
During times of shortage of human tetanus immunoglobulin alternative products may be recommended by the Department of Health. Ensure that the dosing guidance for the product recommended is followed.
References
Immunisation against infectious diseases Chapter 30 ("The Green Book on immunisation"). Last revision of the text 1/6/22. Available at www.gov.uk/government/collections/immunisation-against-infectious-disease-the-green-book Accessed 14/3/25