Haemophilus influenzae type b, prophylaxis
Preferred
rifampicin po (see dosing table)
Give for 4 days.
|
Age |
rifampicin oral dose |
|
1 month up to 3 months |
10 mg/kg OD |
|
3 months up to 12 years |
20 mg/kg (Max 600mg) OD |
|
12 years and older |
600mg OD |
Alternative
For individuals unable to tolerate, or develop an adverse reaction to rifampicin:
First line
ceftriaxone IV or IM
Give for 2 days.
| Age | ceftriaxone IV/IM dose |
| 1 month up to 12 years | 50mg/kg (Max 1g) OD |
| 12 years and older | 1g OD |
Second line
ciprofloxacin* po
Give for 5 days.
| Age | ciprofloxacin oral dose |
| 2 years - 4 years | 125mg po BD |
| 5 years -12 years | 250mg po BD |
| 12 years and older | 500mg po BD |
*ciprofloxacin may induce convulsions in patients with or without a history of convulsions – use with caution
References
Department of Health, Public Health England, Revised recommendations for the prevention of secondary Haemophilus influenzae type B (Hib) disease. Published 22/08/2013. Available at: Haemophilus influenzae type b (Hib): revised recommendations for the prevention of secondary cases - GOV.UK (www.gov.uk)