Craniofacial surgery (except fronto-facial advancement)
Link to General Principles of Surgical Prophylaxis including redosing table and renal dosing for cefazolin.
Continue antibiotics for 2 days post-op or until drains are out, whichever is the longest.
Preferred
cefazolin iv see dosing table below
| Weight | cefazolin iv dose |
| Weight less than 120kg | 30mg/kg (maximum 2g) |
| Weight 120kg or more | 3g |
For post-op doses: co-amoxiclav 30mg/kg (max 1.2g) iv TDS (BD for patients 1-2 months old) for 2 days post-op or until the drains are out, whichever is the longest.
Alternative
For penicillin allergy (non-severe)
cefazolin iv see dosing table below
| Weight | cefazolin iv dose |
| Weight less than 120kg | 30mg/kg (maximum 2g) |
| Weight 120kg or more | 3g |
For post-op doses: ceftriaxone 50mg/kg (max 2g) iv OD for 2 days post-op or until the drains are out, whichever is the longest.
For penicillin allergy (severe) or MRSA positive
teicoplanin 10mg/kg (Max 800mg) iv BD for 3 doses then reduce to 10mg/kg (Max 800mg) iv OD. Duration of 2 days post-op or until the drains are out, whichever is the longest.
AND
metronidazole 30mg/kg iv (Max 500mg) in theatre then continue metronidazole at 7.5mg/kg (Max 500mg) iv TDS. Duration of 2 days post-op or until the drains are out, whichever is the longest.