Sepsis 1 month and over

cefotaxime 50mg/kg (Max 4g) iv bolus initially in ED 

then either:

• Continue cefotaxime 50mg/kg (Max 4g) iv QDS (maximum per day: 12g), OR
• If stable on the ward AND 41 weeks or over corrected gestational age AND NOT receiving iv calcium change to ceftriaxone 80mg/kg (Max 4g) iv OD 

For MRSA positive patients: ADD vancomycin iv 

If meningitis suspected then see Meningitis (1 month and over)

Review once microbiology results available.

For penicillin allergy (severe)

ciprofloxacin 10mg/kg (Max 400mg) iv TDS AND vancomycin iv 

*Ciprofloxacin may induce convulsions in patients with or without a history of convulsions – use with caution

OR

chloramphenicol 25mg/kg (Max 1g) iv single dose THEN consult Paediatric ID/Micro

For MRSA positive patients

ciprofloxacin 10mg/kg (Max 400mg) iv TDS AND vancomycin iv 

*Ciprofloxacin may induce convulsions in patients with or without a history of convulsions – use with caution

If meningitis suspected then see Meningitis (1 month and over)

Review once microbiology results available.